The peripheral nervous system (PNS) is the body's information superhighway, transmitting signals across our bodies much like fiber optic cables. Nerves are everywhere within us, permeating our tissues, enmeshing our cells in a web of neurites, and connecting distant parts of the body to each other. Without the PNS, our internal communications would break down.
Despite many advances in neuroscience, the intense focus on the biology of the brain has left the PNS by the wayside. Although we now have a deeper grasp of neural biochemistry, molecular biology, and electrophysiology, the PNS is still seen as a passive transmission pipeline for information heading to and from the brain.
Our founder Flagship Pioneering asked:
What if, instead of being mere conduits of the central nervous system's commands, peripheral nerves are independent biological actors and even decision makers?
It turns out, peripheral neurons are far from passive.
From cancer to gut inflammation and other areas of disease, nerves function in ways far beyond canonical contexts and mechanisms. The tissues they permeate make use of biochemical neural pathways and signals, and many non-neuronal cells communicate with and mimic nerves in disease settings.
This is a novel way of thinking about neural signaling as outside—or exo—traditional neurobiology, giving rise to the term exoneural biology to describe the field.
Cygnal speaks the language of neurons.