Cygnal Therapeutics is a privately held, early-stage biotechnology company pioneering the field of Exoneural Biology – the neural regulation of cancer, immunity, and regeneration. Cygnal is developing drugs to manipulate Exoneural Biology for the treatment of cancer, immunological diseases, and regenerative processes. Cygnal Therapeutics was founded by Flagship Pioneering, in the VentureLabs innovation foundry, which has created over 50 groundbreaking companies that are developing novel and proprietary biological, industrial, and engineering approaches to solve major needs in human health and sustainability.
Cygnal is seeking a Research Associate or Associate Scientist to join our In Vivo team, working closely with our scientists to develop and perform assays and identify targets and therapeutics. The candidate may come from an oncology background or an immunology background, but must be independent, goal oriented, and willing to work in a highly dynamic and fast-paced entrepreneurial environment.
The Research Associate responsibilities and qualifications include:
- MS/BS and a minimum of 3-5 years related laboratory experience, working in an animal laboratory in biotech/pharma or academic environment
- Proficiency in handling rodents (rats, and mice) and performing dose-finding tolerability studies, PK/PD studies, and efficacy studies
- Desire to learn new techniques and participate in cutting-edge projects
- Knowledge of Institutional Animal Care and Use Committee, or IACUC procedures and mandated responsibilities
- Experienced in running cancer models including tumor implantation, measurement, compound administration by various routes (IV, PO, IP, SC) blood collection, and tissues dissection
- Efficient in orthotopic implantation surgery preferred, such as osmotic pump implantation, prostate pancreatic injections, mammary fat pad, lung, etc.
- Experience with in vivo fluorescence imaging. The use of IVIS Spectrum CT preferred
- Experience with syngeneic tumors, genetic mouse models of cancer, and/or patient-derived xenografts
- Experienced in running rodent models of inflammation, including e.g. colitis, dermatitis, and airway inflammation models
- Experienced with immunological dissection techniques such as harvesting of lymph nodes, spleen, bone marrow etc.
- Familiar with adoptive cell transfer models and techniques
To learn more about this exciting career opportunity please submit your resume and cover letter to firstname.lastname@example.org.